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Activin Receptor Type IA antibody [9J17]

Anti-Activin Receptor Type IA antibody [9J17] used in IHC (Paraffin sections) (IHC-P). GTX52503

Cat No. GTX52503

Host

Mouse

Clonality

Monoclonal

Clone Name

9J17

Isotype

IgG1

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:100 - 1:1000
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant hu-ALK2 extra cellular domain

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ACTRI , ACVR1 , ACVR1A , ACVRLK2 , ALK2 , FOP , SKR1 , TSRI , activin A receptor type 1 , Activin A receptor type I , Activin Receptor type IA

Cellular Localization

Membrane

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

Database

  • Gene ID: 90 ACVR1
  • UniProt: Q04771 ACVR1

Research Area

DATA IMAGES

Anti-Activin Receptor Type IA antibody [9J17] used in IHC (Paraffin sections) (IHC-P). GTX52503

GTX52503 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52503 Activin Receptor Type IA antibody [9J17].

REFERENCE

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REVIEW

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SDS
PBS.pdf