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Activin Receptor Type IA antibody, Internal

Anti-Activin Receptor Type IA antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX88867
Anti-Activin Receptor Type IA antibody, Internal used in Western Blot (WB). GTX88867

Cat No. GTX88867

Host

Goat

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.3-1μg/ml
IHC-P 4-6μg/ml

Note :

IHC-P
Human Testis shows preferential staining of cytoplasm in primary spermatocytes..

Not tested in other applications.

Calculated MW

57 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88867-PEP).

Predict Reactivity

Mouse, Rat, Dog(>80% identity)

PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence according to NP_001096.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

RRID

AB_10723561

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

activin A receptor type 1 , ACTRI , ACVR1A , ACVRLK2 , ALK2 , FOP , SKR1 , TSRI

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

Database

  • Gene ID: 90 ACVR1
  • UniProt: Q04771 ACVR1

Research Area

DATA IMAGES

Anti-Activin Receptor Type IA antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX88867

GTX88867 IHC-P Image

IHC-P analysis of human testis using GTX88867 Activin A Receptor type I antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 4μg/ml

Anti-Activin Receptor Type IA antibody, Internal used in Western Blot (WB). GTX88867

GTX88867 WB Image

WB analysis of human umbilical cord lysate using GTX88867 Activin A Receptor type I antibody, Internal.
Dilution : 0.3μg/ml
Loading : 35μg protein in RIPA buffer

REFERENCE

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 349