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Activin Receptor Type IA antibody

Anti-Activin Receptor Type IA antibody used in IHC (Frozen sections) (IHC-Fr). GTX107815
Anti-Activin Receptor Type IA antibody used in Western Blot (WB). GTX107815
Anti-Activin Receptor Type IA antibody used in Western Blot (WB). GTX107815

Cat No. GTX107815

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-Fr

Reactivity

Mouse, Rat
Package
100 μl ($329),
25 μl ($169)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-Fr 1:100-1:1000
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

Positive Control

mouse heart , rat liver

Predict Reactivity

Human, Bovine, Xenopus laevis, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.9 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Activin Receptor type IA. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2036157

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

activin A receptor type 1 , ACTRI , ACVR1A , ACVRLK2 , ALK2 , FOP , SKR1 , TSRI

Cellular Localization

Membrane

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq]

Database

  • Gene ID: 90 ACVR1
  • UniProt: Q04771 ACVR1

Research Area

DATA IMAGES

Anti-Activin Receptor Type IA antibody used in IHC (Frozen sections) (IHC-Fr). GTX107815

GTX107815 IHC-Fr Image

Activin A Receptor type I antibody detects Activin A Receptor type I protein by immunohistochemical analysis.
Sample: Frozen sectioned adult mouse retina.
Green: Activin A Receptor type I protein stained by Activin A Receptor type I antibody (GTX107815) diluted at 1:250.
Red: Protein kinase C alpha staining.
Blue: Fluoroshield with DAPI (GTX30920).

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Activin Receptor Type IA antibody used in Western Blot (WB). GTX107815

GTX107815 WB Image

Activin A Receptor type I antibody detects ACVR1 protein by Western blot analysis.
A. 50 μg rat liver lysate/extract
7.5 % SDS-PAGE
Activin A Receptor type I antibody (GTX107815) dilution: 1:1000

Anti-Activin Receptor Type IA antibody used in Western Blot (WB). GTX107815

GTX107815 WB Image

Mouse tissue extract (50 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Activin A Receptor type I antibody (GTX107815) diluted at 1:500.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 329
$ 169