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Activin Receptor Type IB antibody [N2C3]

Anti-Activin Receptor Type IB antibody [N2C3] used in Western Blot (WB). GTX102873
Anti-Activin Receptor Type IB antibody [N2C3] used in IHC (Paraffin sections) (IHC-P). GTX102873
Anti-Activin Receptor Type IB antibody [N2C3] used in Western Blot (WB). GTX102873

Cat No. GTX102873

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse
Package
100 μl ($329),
25 μl ($169)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

Positive Control

SK-N-SH , mouse brain

Predict Reactivity

Rat, Pig, Xenopus laevis, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Activin Receptor Type IB. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

activin A receptor type 1B , ACTRIB , ACVRLK4 , ALK4 , SKR2

Cellular Localization

Membrane

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq]

Database

  • Gene ID: 91 ACVR1B
  • UniProt: P36896 ACVR1B

Research Area

DATA IMAGES

Anti-Activin Receptor Type IB antibody [N2C3] used in Western Blot (WB). GTX102873

GTX102873 WB Image

Sample (50 ug of whole cell lysate)
A: mouse brain
7.5% SDS PAGE
GTX102873 diluted at 1:1000

Anti-Activin Receptor Type IB antibody [N2C3] used in IHC (Paraffin sections) (IHC-P). GTX102873

GTX102873 IHC-P Image

ACVR1B antibody [N2C3] detects ACVR1B protein at cytosol on human colon carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human colon carcinoma.
ACVR1B antibody [N2C3] (GTX102873) dilution: 1:250.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Activin Receptor Type IB antibody [N2C3] used in Western Blot (WB). GTX102873

GTX102873 WB Image

Sample (30 ug of whole cell lysate)
A: SK-N-SH
7.5% SDS PAGE
GTX102873 diluted at 1:3000

REFERENCE

There are currently no references for Activin Receptor Type IB antibody [N2C3] (GTX102873). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Activin Receptor Type IB antibody [N2C3] (GTX102873). Be the first to share your experience with this product.
SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 329
$ 169