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Activin Receptor Type IC antibody

Anti-Activin Receptor Type IC antibody used in Western Blot (WB). GTX103442
Anti-Activin Receptor Type IC antibody used in Western Blot (WB). GTX103442
Anti-Activin Receptor Type IC antibody used in IHC (Paraffin sections) (IHC-P). GTX103442

Cat No. GTX103442

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Rat
Package
100 μl ($329),
25 μl ($169)
See all Activin Receptor Type IC products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

55 kDa. ( Note )

Positive Control

HepG2 , rat brain

Predict Reactivity

Mouse, Bovine, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

1XPBS (pH7), 1% BSA, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Activin Receptor Type IC. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_11178087

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

activin A receptor type 1C , ACVRLK7 , ALK7

Cellular Localization

Membrane

Background

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM]

Database

Research Area

DATA IMAGES

Anti-Activin Receptor Type IC antibody used in Western Blot (WB). GTX103442

GTX103442 WB Image

Rat tissue extract (50 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Activin A Receptor Type IC antibody (GTX103442) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Activin Receptor Type IC antibody used in Western Blot (WB). GTX103442

GTX103442 WB Image

Sample (30 ug of whole cell lysate)
A: HepG2
7.5% SDS PAGE
GTX103442 diluted at 1:1000

Anti-Activin Receptor Type IC antibody used in IHC (Paraffin sections) (IHC-P). GTX103442

GTX103442 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using Activin A Receptor Type IC(GTX103442) antibody at 1:500 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

REFERENCE

Application Reference

Principe M et al. Endocr Relat Cancer 2018; 25 (9) : 795-806 ALK7 expression in prolactinoma is associated with reduced prolactin and increased proliferation.
Application : IHC-P
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 329
$ 169