APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100 - 1:1000 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
Product Note
This antibody was selected for its ability to detect human Activin RIIB. Weak cross reactivity was found to Activin RIIA
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
200 μg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant Activin RIIB extra cellular domain
Purification
Protein G purified
From tissue culture supernatant
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
ACTRIIB , ACVR2B , ActRIIB , HTX4 , activin A receptor type 2B , Activin Receptor Type IIB , Activin receptor 2B , Activin RIIB
Cellular Localization
Cell membrane
Background
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Database
-
Gene ID: 93
ACVR2B
-
UniProt: Q13705
ACVR2B
Research Area
DATA IMAGES
![Anti-Activin Receptor Type IIB antibody [6L11] used in IHC (Paraffin sections) (IHC-P). GTX52510](/templates/default/js/lightbox/images/loading.gif "Anti-Activin Receptor Type IIB antibody [6L11] used in IHC (Paraffin sections) (IHC-P). GTX52510")
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GTX52510 IHC-P Image
IHC-P analysis of formalin fixed human placenta tissue using GTX52510 Activin Receptor Type IIB antibody [6L11].
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REFERENCE
There are currently no references for Activin Receptor Type IIB antibody [6L11] (GTX52510). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Activin Receptor Type IIB antibody [6L11] (GTX52510). Be the first to share your experience with this product.
![Anti-Activin Receptor Type IIB antibody [6L11] used in IHC (Paraffin sections) (IHC-P). GTX52510](/upload/website/prouct_img/small/GTX52510/GTX52510_20191119_IHC-P_w_23060900_788.webp "Anti-Activin Receptor Type IIB antibody [6L11] used in IHC (Paraffin sections) (IHC-P). GTX52510")
![Anti-Activin Receptor Type IIB antibody [6L11] used in IHC (Paraffin sections) (IHC-P). GTX52510](/upload/website/prouct_img/normal/GTX52510/GTX52510_20191119_IHC-P_w_23060900_788.webp "Anti-Activin Receptor Type IIB antibody [6L11] used in IHC (Paraffin sections) (IHC-P). GTX52510")