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Activin Receptor Type IIB antibody [N1C1]

Anti-Activin Receptor Type IIB antibody [N1C1] used in Western Blot (WB). GTX105330
Anti-Activin Receptor Type IIB antibody [N1C1] used in Western Blot (WB). GTX105330
Anti-Activin Receptor Type IIB antibody [N1C1] used in Western Blot (WB). GTX105330
Anti-Activin Receptor Type IIB antibody [N1C1] used in IHC (Paraffin sections) (IHC-P). GTX105330

Cat No. GTX105330

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse
Package
100 μl ($319),
25 μl ($169)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:50000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

58 kDa. ( Note )

Positive Control

U87-MG , SK-N-SH , IMR-32 , SK-N-AS , mosue cerebellum , mouse testis , ACVR2B-transfected 293T

Predict Reactivity

Rat, Bovine, Chicken, Pig(>80% identity)
PROPERTIES

Form

Liquid

Buffer

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.91 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Activin Receptor Type IIB. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

activin A receptor type 2B , ACTRIIB , ActR-IIB , HTX4

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

Database

  • Gene ID: 93 ACVR2B
  • UniProt: Q13705 ACVR2B

Research Area

DATA IMAGES
Anti-Activin Receptor Type IIB antibody [N1C1] used in Western Blot (WB). GTX105330

GTX105330 WB Image

Non-transfected (–) and transfected (+) 293T whole cell extracts (30 µg) were separated by 10% SDS-PAGE, and the membrane was blotted with Activin Receptor Type IIB antibody [N1C1] (GTX105330) diluted at 1:50000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Activin Receptor Type IIB antibody [N1C1] used in Western Blot (WB). GTX105330

GTX105330 WB Image

Mouse tissue extract (50 µg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Activin Receptor Type IIB antibody [N1C1] (GTX105330) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Activin Receptor Type IIB antibody [N1C1] used in Western Blot (WB). GTX105330

GTX105330 WB Image

Various whole cell extracts (30 µg) were separated by 10% SDS-PAGE, and the membrane was blotted with Activin Receptor Type IIB antibody [N1C1] (GTX105330) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Activin Receptor Type IIB antibody [N1C1] used in IHC (Paraffin sections) (IHC-P). GTX105330

GTX105330 IHC-P Image

Activin Receptor Type IIB antibody [N1C1] detects Activin Receptor Type IIB protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse placenta.
Activin Receptor Type IIB stained by Activin Receptor Type IIB antibody [N1C1] (GTX105330) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE
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SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 319
$ 169