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Agrin antibody [Agr-247]

Cat No. GTX12364

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 Agr-247

Isotype

 IgG1

Application

 ICC/IF

Reactivity

 Mouse, Rat
Package
100 μg ($349)
See all Agrin products

APPLICATION

Application Note

ICC: Use at a concentration of 2 μg/ml. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

209 kDa. ( Note )

Positive Control

Mouse Brain Tissue Extract

Specificity/Sensitivity

GTX12364 regognises agrin.

PROPERTIES

Form

Liquid

Buffer

Preservative: NoneConstituents: 50% Glycerol, PBS, 0.1mM PMSF

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Recombinant rat agrin, C-terminal construct.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Agrin , Agr , Agrn

Cellular Localization

Synaptic basal lamina at the neuromuscular junction.

Background

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Package List Price ($)
$ 349