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Alpha, Beta - Synuclein antibody [3B6]

Anti-Alpha, Beta - Synuclein antibody [3B6] used in Western Blot (WB). GTX50063

Cat No. GTX50063

Host

Mouse

Clonality

Monoclonal

Clone Name

3B6

Isotype

IgG1

Application

WB, ELISA, WB-Ag

Reactivity

Human, Mouse, Rat
Package
100 μl ($319)

APPLICATION

Application Note

We recommend the following starting dilutions:
Western Blot: Use at 1:1,000 ~ 2,000.

Optimal working concentrations should be determined experimentally by the end user.

PROPERTIES

Form

Liquid

Buffer

Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human a-synuclein (119-140aa) purified from E. coli

Purification

By protein-G affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

S , Non A beta component of AD amyloid , Parkinson disease familial 1 , a,b - synuclein , SNCA , Beta synuclein , Non A4 component of amyloid precursor , a,b synuclein , PD1 , SNCB , NACP , PARK4 , SNCB protein , Alpha synuclein , PARK1 , Synuclein beta, , Parkinson disease familial1 , a,b synuclein

Cellular Localization

Membrane-bound in dopaminergic neurons. Also found in the nucleus.

Background

alpha-synuclein (amino acids 119-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A? component of amyloid plaques is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.

Research Area

DATA IMAGES

Anti-Alpha, Beta - Synuclein antibody [3B6] used in Western Blot (WB). GTX50063

GTX50063 WB Image

The recombinant human synuclein family (alpha-,beta- and gamma-) (each 20ng), Mouse brain and Rat brain (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human alpha,?-synuclein (1:1000). Proteins were visualized using a

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 319