Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant human a-synuclein (119-140aa) purified from E. coli
By protein-G affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
S , Non A beta component of AD amyloid , Parkinson disease familial 1 , a,b - synuclein , SNCA , Beta synuclein , Non A4 component of amyloid precursor , a,b synuclein , PD1 , SNCB , NACP , PARK4 , SNCB protein , Alpha synuclein , PARK1 , Synuclein beta, , Parkinson disease familial1 , a,b synuclein
Membrane-bound in dopaminergic neurons. Also found in the nucleus.
alpha-synuclein (amino acids 119-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A? component of amyloid plaques is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.