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Androgen Receptor (ARv7 Splice Variant) antibody [RM7]

Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX33604
Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in Western Blot (WB). GTX33604
Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in IHC (Paraffin sections) (IHC-P). GTX33604
Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in IHC (Paraffin sections) (IHC-P). GTX33604

Cat No. GTX33604

Host

Rabbit

Clonality

Monoclonal

Clone Name

RM7

Isotype

IgG

Application

WB, ICC/IF, IHC-P, IP, ChIP assay, IHC

Reactivity

Human
Package
100 μl ($449)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
ICC/IF 1:100 - 1:1000
IHC-P Assay dependent
IP Assay dependent
ChIP assay Assay dependent
IHC 1:500 - 1:1000
Not tested in other applications.

Calculated MW

99 kDa. ( Note )

Specificity/Sensitivity

This antibody reacts to androgen receptor splice variant 7 (AR-V7). No cross reactivity with wild type androgen receptor.

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 0.09% sodium azide, 50% Glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A peptide corresponding to AR splice variant 7

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

AIS,AR,AR8,DHTR,HUMARA,HYSP1,KD,NR3C4,SBMA,SMAX1,TFM,androgen receptor,Androgen Receptor

Cellular Localization

Nucleus,Cytoplasm

Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

Database

Research Area

DATA IMAGES

Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX33604

GTX33604 ICC/IF Image

ICC/IF analysis of PC-3 and 22RV1 cells using GTX33604 Androgen Receptor (ARv7 Splice Variant) antibody [RM7].
Red : Primary antibody
Green : Actin

Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in Western Blot (WB). GTX33604

GTX33604 WB Image

WB analysis of 22RV1, DU145, and PC-3 whole cell lysates using GTX33604 Androgen Receptor (ARv7 Splice Variant) antibody [RM7].

Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in IHC (Paraffin sections) (IHC-P). GTX33604

GTX33604 IHC-P Image

IHC-P analysis of formalin fixed and paraffin embedded sections of 22RV1 and DU145 cells using GTX33604 Androgen Receptor (ARv7 Splice Variant) antibody [RM7].

Anti-Androgen Receptor (ARv7 Splice Variant) antibody [RM7] used in IHC (Paraffin sections) (IHC-P). GTX33604

GTX33604 IHC-P Image

IHC-P analysis of bone metastasis prostate cancer using GTX33604 Androgen Receptor (ARv7 Splice Variant) antibody [RM7].

REFERENCE

REVIEW

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Package List Price ($)
$ 449