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Androgen Receptor antibody [2H8]

Anti-Androgen Receptor antibody [2H8] used in Western Blot (WB). GTX83309
Anti-Androgen Receptor antibody [2H8] used in IHC (Paraffin sections) (IHC-P). GTX83309
Anti-Androgen Receptor antibody [2H8] used in Western Blot (WB). GTX83309
Anti-Androgen Receptor antibody [2H8] used in IHC (Paraffin sections) (IHC-P). GTX83309

Cat. No. GTX83309

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2H8

Isotype

 IgG1

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μl ($419)
See all Androgen Receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/500 - 1/2000
IHC-P 1/200 - 1/1000
ELISA 1/10000
Not tested in other applications.

Calculated MW

99 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.03% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Purified recombinant fragment of human AR(AA : 221-321) expressed in E. Coli.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

androgen receptor , AIS , AR8 , DHTR , HUMARA , HYSP1 , KD , NR3C4 , SBMA , SMAX1 , TFM

Cellular Localization

Nucleus,Cytoplasm

Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Androgen Receptor antibody [2H8] used in Western Blot (WB). GTX83309

GTX83309 WB Image

WB analysis of Androgen receptor (aa221-321)-hIgGFc transfected HEK293 cell lysate using GTX83309 Androgen Receptor antibody [2H8].

Anti-Androgen Receptor antibody [2H8] used in IHC (Paraffin sections) (IHC-P). GTX83309

GTX83309 IHC-P Image

IHC-P analysis of human Prostate tissue using GTX83309 Androgen Receptor antibody [2H8].

Anti-Androgen Receptor antibody [2H8] used in Western Blot (WB). GTX83309

GTX83309 WB Image

WB analysis of K562 (1), Jurkat (2) and LNCaP (3) cell lysate using GTX83309 Androgen Receptor antibody [2H8].

Anti-Androgen Receptor antibody [2H8] used in IHC (Paraffin sections) (IHC-P). GTX83309

GTX83309 IHC-P Image

IHC-P analysis of human human testis (left) and prostate cancer (right) tissue using GTX83309 Androgen Receptor antibody [2H8].

REFERENCE

Application Reference

Pramod SV et al. Res Rep Urol 2023; 15 : 485-494 Cytoplasmic Androgen Receptor, CD24 Expression and Smoking Intensity to Urothelial Carcinoma of the Bladder Invasiveness: A Cross-Sectional Study.
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 419