Androgen Receptor antibody [AR 441]

Name: Androgen Receptor antibody [AR 441]
Brand: GeneTex
SKU: GTX29474
Price: 399.00 USD
Rating: 5 (1 reviews)

Anti-Androgen Receptor antibody [AR 441] used in IHC (Paraffin sections) (IHC-P). GTX29474

Cat. No. GTX29474

Reference 3

Host	Mouse
Clonality	Monoclonal
Clone Name	AR 441
Isotype	IgG1
Application	IHC-P
Reactivity	Human
Package	250 μl ($399)

See all Androgen Receptor products

View product citations for antibody GTX29474 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
IHC-P	1:100‐1:200
Note : IHC-P Recommendations for antigen retrieval : Citrate Buffer pH 6.0 at room temperature for 30 mins.

Not tested in other applications.

Calculated MW

99 kDa. ( Note )

Product Note

This antibody reacts with full length AR and also with the newly described A form of the receptor. This antibody does not cross-react with estrogen, progesterone or glucocorticoid receptors.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BALB/C mice were injected with a synthetic peptide corresponding to the human androgen receptor.

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_367520

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

androgen receptor , AIS , AR8 , DHTR , HUMARA , HYSP1 , KD , NR3C4 , SBMA , SMAX1 , TFM

Cellular Localization

Nucleus , Cytoplasm

Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

Database

Gene ID: 367 AR
UniProt: P10275 AR

Research Area

DATA IMAGES

GTX29474 IHC-P Image

IHC-P analysis of human prostate carcinoma tissue using GTX29474 Androgen Receptor antibody [AR 441].

REFERENCE

Application Reference

Yokoyama A et al. J Endocr Soc 2021; 5 (11) : bvab150 Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.

Application : IHC-P

Reactivity : Human

Yuan M et al. Med Sci Monit 2019; 25 : 4438-4449 Phospholipase C (PLC)ε Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line.

Onodera Y et al. Cancer Med 2016; 5 (8) : 1973-82 TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation.

Application : IHC-P

Reactivity : Human

Submit a Reference

REVIEW