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Angiogenin antibody [MANG-1]

Cat. No. GTX42776

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MANG-1

Isotype

 IgM

Application

 IHC-P, IHC-Fr, ELISA

Reactivity

 Human
Package
50 μg ($399)
See all Angiogenin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1/30
IHC-Fr 1/60
ELISA Assay dependent

Note :

IHC-P
Proteinase K pretreatment for antigen retrieval is recommended for use with paraffin sections.

IHC-Fr
Mouse anti Angiogenin, clone MANG1 stains single cells on human tonsil sections andendothelial cells in human terminal placenta. MANG-1 also demonstrates intense staining on carcinoma cells and of endothelial cells in intratumoral vessels (Marioni et al.
Not tested in other applications.

Calculated MW

17 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.3 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human angiogenin

Purification

Tissue Culture Supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

angiogenin , ALS9 , HEL168 , RAA1 , RNASE4 , RNASE5

Cellular Localization

Secreted , Nucleus , Nucleolus

Background

The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399