Functional: Inhibits the binding of mouse angiopoietin-2 to mouse Tie-2. ND50 = 50-60ng/ml (for 10ng/ml of mouse Angiopoietin-2) inhibits the binding of human angiopoietin-2 to human Tie-2. ND50 = 8-12ng/ml (for 10ng/ml of human Angiopoietin-2) ND50: 50% neutralizing dose of antibody for a given concentration of ligand (here Angiopoietin-2).
Recognizes human and mouse angiopoietin-2. Does not detect human angiopoietin-1.
PBS containing 10% glycerol.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant human angiopoietin-2.
Protein A-affinity purified.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]