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Angiotensin I/II/III antibody [B938M]

Cat. No. GTX44411

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 B938M

Isotype

 IgG1

Application

 ELISA

Reactivity

 Human
Package
100 μg ($489)
See all Angiotensin I/II/III products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ELISA 1:10-1:100
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Product Note

Crossreacts with angiotensin I and III in ELISA. Incomplete mapping indicatesreactivity is to a conserved region of all angiotensin molecules (AI/II, a.a. 3-8, Sequence: Val-Tyr-Ile-His-Pro).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide representing Angiotensin II, conjugated to rabbit albumin.

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

angiotensinogen , ANHU , SERPINA8 , hFLT1

Cellular Localization

Secreted

Background

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Application Reference

Briquez PS et al. Sci Adv 2022; 8 (40) : eabn3777 Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 489