APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 21-175 of human AGR2 (NP_006399.1).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
anterior gradient 2, protein disulphide isomerase family member , AG-2 , AG2 , GOB-4 , HAG-2 , HEL-S-116 , HPC8 , PDIA17 , XAG-2
Cellular Localization
Secreted,Endoplasmic reticulum
Background
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
Database
Research Area
DATA IMAGES
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GTX32995 IHC-P Image
IHC-P analysis of human lung cancer tissue using GTX32995 Anterior Gradient 2 antibody.
Dilution : 1:100
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GTX32995 WB Image
WB analysis of various sample lysates using GTX32995 Anterior Gradient 2 antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX32995 IHC-P Image
IHC-P analysis of mouse lung tissue using GTX32995 Anterior Gradient 2 antibody.
Dilution : 1:100
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GTX32995 ICC/IF Image
ICC/IF analysis of L929 cells using GTX32995 Anterior Gradient 2 antibody.
Blue : DAPI
Dilution : 1:100
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GTX32995 ICC/IF Image
ICC/IF analysis of U2OS cells using GTX32995 Anterior Gradient 2 antibody.
Blue : DAPI
Dilution : 1:100
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REFERENCE
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REVIEW
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