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Apolipoprotein E antibody [WUE-4] (Low endotoxin, azide free)

Anti-Apolipoprotein E antibody [WUE-4] (Low endotoxin, azide free) used in ELISA (ELISA). GTX42746
Anti-Apolipoprotein E antibody [WUE-4] (Low endotoxin, azide free) used in ELISA (ELISA). GTX42746

Cat No. GTX42746

Host

Mouse

Clonality

Monoclonal

Clone Name

WUE-4

Isotype

IgG1

Application

WB, ELISA, Neutralizing/Inhibition

Reactivity

Human, Mouse
Package
500 μg ($639)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ELISA 1/100-1/1,000
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
Mouse anti Human Apolipoprotein E antibody, clone WUE-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB,E cell receptor (Krul et al. 1998).

Not tested in other applications.

Calculated MW

36 kDa. ( Note )

Product Note

This antibody recognizes an epitope within amino acids 140-160 of human Apolipoprotein E, a major component of very low-density lipoproteins (VLDLs).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified ApoHDL fraction.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

apolipoprotein E , AD2 , APO-E , ApoE4 , LDLCQ5 , LPG

Cellular Localization

Secreted

Background

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

Database

Research Area

DATA IMAGES

Anti-Apolipoprotein E antibody [WUE-4] (Low endotoxin, azide free) used in ELISA (ELISA). GTX42746

GTX42746 ELISA Image

Sandwich ELISA analysis of human apolipoprotein E using Mouse anti Human apolipoprotein E (GTX42746) as a capture reagent and biotinylated Goat anti Human Apolipoprotein E as a detection reagent. A serum sample 1/150 (green) and a plasma sample 1/150 (orange) are shown.

Anti-Apolipoprotein E antibody [WUE-4] (Low endotoxin, azide free) used in ELISA (ELISA). GTX42746

GTX42746 ELISA Image

ELISA analysis of human apolipoprotein E protein using GTX42746 Apolipoprotein E antibody [WUE-4] (Low endotoxin, azide free).

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 639
Custom Conjugations