APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| 1 - 2 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Lysate(GTX27918) , Human Liver Tissue Slide
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
APO-E antibody was raised against a 19 amino acid peptide near the carboxy terminus of human APO-E.The immunogen is located within amino acids 220 - 270 of APO-E.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
apolipoprotein E , AD2 , APO-E , ApoE4 , LDLCQ5 , LPG
Cellular Localization
Secreted
Background
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX17206 IHC-P Image
IHC-P analysis of human liver tissue using GTX17206 Apolipoprotein E antibody.
Working concentration : 2.5 μg/ml
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GTX17206 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX17206 Apolipoprotein E antibody.
Working concentration : 5 μg/ml
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GTX17206 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX17206 Apolipoprotein E antibody.
Working concentration : 20 μg/ml
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GTX17206 WB Image
WB analysis of human brain tissue lysate using GTX17206 Apolipoprotein E antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml
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REFERENCE
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REVIEW
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