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Ataxin 1 antibody

Anti-Ataxin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX87190
Anti-Ataxin 1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87190

Cat No. GTX87190

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application ICC/IF, IHC-P
Reactivity Human, Mouse
Package
100 μg ($339)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 1:100~1:500
IHC-P 1:50~1:100
Not tested in other applications.

Calculated MW

87 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human Ataxin 1 (742-791).

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ATX1,ATXN1,D6S504E,SCA1,ataxin 1,Ataxin 1

Cellular Localization

Cytoplasm,Nucleus

Background

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]

Database

Research Area

DATA IMAGES
Anti-Ataxin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX87190

GTX87190 IHC-P Image

IHC-P analysis of human lung carcinoma tissue using GTX87190 Ataxin 1 antibody. The picture on the right is blocked with the synthesized peptide.

Anti-Ataxin 1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87190

GTX87190 ICC/IF Image

ICC/IF analysis of NIH3T3 cells using GTX87190 Ataxin 1 antibody. The picture on the right is blocked with the synthesized peptide.

REFERENCE
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REVIEW
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Package List Price ($)
$ 339