GeneTex

  • Country / Location Selection

United States (US)

Axin 2 antibody

Anti-Axin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30080
Anti-Axin 2 antibody used in Western Blot (WB). GTX30080
Anti-Axin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30080

Cat. No. GTX30080

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all Axin 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

94 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human AXIN2 (NP_004646.3).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

axin 2 , AXIL , ODCRCS

Cellular Localization

Cytoplasm

Background

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Axin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30080

GTX30080 IHC-P Image

IHC-P analysis of rat brain tissue using GTX30080 Axin 2 antibody.
Dilution : 1:100

Anti-Axin 2 antibody used in Western Blot (WB). GTX30080

GTX30080 WB Image

WB analysis of various sample lysates using GTX30080 Axin 2 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-Axin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30080

GTX30080 IHC-P Image

IHC-P analysis of mouse spinal cord tissue using GTX30080 Axin 2 antibody.
Dilution : 1:100

REFERENCE

There are currently no references for Axin 2 antibody (GTX30080). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Axin 2 antibody (GTX30080). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399