APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
This antibody is specific for Gb4Cer and does not cross react with various glycosphingolipids: LacCer, Gb3Cer, Gg3Cer, Gg4Cer, GM1, GM2, and GM3, determined by ELISA assay. (PMID: 33564002)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No preservatives
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Gb4Cer-labeled very long chain fatty acid (VLCFA)
Purification
Purified by hydroxyapatite chromatography
From tissue culture supernatant
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
B3GALNT1,B3GALT3,GLCT3,GLOB,Gb4Cer,P,P1,beta1,3Nacetylgalactosaminyltransferase 1 (globoside blood group),beta3GalT3,galT3,beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
Cellular Localization
Golgi apparatus membrane
Background
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. [provided by RefSeq, Mar 2017]
Database
Research Area
REFERENCE
There are currently no references for B3GALNT1 antibody [PA5] (GTX04882). Be the first to share your publications with this product.
REVIEW
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