APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 μg/mL |
| 10 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rat, Bovine, Pig(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
BACE1 antibody was raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE. The immunogen is located within the last 50 amino acids of BACE.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
beta-secretase 1 , ASP2 , BACE , HSPC104
Cellular Localization
Cell membrane,Endoplasmic reticulum,Endosome,Lysosome
Background
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Database
Research Area
DATA IMAGES
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GTX17545 WB Image
WB analysis of human brain tissue lysate in the absence (A) or presence (B) of blocking peptide and in mouse 3T3 cell lysate (C) using GTX17545 BACE1 antibody.
Dilution : 1 μg/mL
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GTX17545 ICC/IF Image
ICC/IF analysis of 3T3 cells using GTX17545 BACE1 antibody.
Dilution : 20 μg/ml
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GTX17545 ICC/IF Image
ICC/IF analysis of 3T3 cells using GTX17545 BACE1 antibody.
Dilution : 10 μg/ml
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GTX17545 WB Image
WB analysis of various sample lysates using GTX17545 BACE1 antibody.
Loading : 15μg of lysates per lane
Dilution : 1 μg/ml
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GTX17545 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX17545 BACE1 antibody.
Dilution : 2.5 μg/ml
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REFERENCE
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REVIEW
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