GeneTex
  • Country / Location Selection

United States (US)

BACE2 antibody

Anti-BACE2 antibody used in Immunohistochemistry (IHC). GTX28025
Anti-BACE2 antibody used in Western Blot (WB). GTX28025

Cat No. GTX28025

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC
Reactivity Human, Mouse, Rat
Package
100 μg ($329)
APPLICATION

Application Note

Western blot: 1:500-1:1,000

Calculated MW

56 kDa. ( Note )

Positive Control

Human heart tissue lysate.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: APTPGPGTPAERHADG, corresponding to amino acids 44-59 of Human BACE 2.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Beta-Secretase 2,Aeplc,Alp56,Asp1,Asp21,Bae2,Cda13,Ceap1,Drap,Bace2

Background

Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at b- and g-sites by proteases. The long-sought-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within Ab (8). BACE2 locates on chromosome 21q22.3, the so-called Down critical region, suggesting thatBACE2 and Ab may also contribute to the pathogenesis of Down syndrome (6,7)

Database

Research Area

DATA IMAGES
Anti-BACE2 antibody used in Immunohistochemistry (IHC). GTX28025

GTX28025 IHC Image

Immunohistochemical staining of mouse heart with Rabbit anti Human BACE2 (GTX28025)

Anti-BACE2 antibody used in Western Blot (WB). GTX28025

GTX28025 WB Image

Western blot analysis of BACE-2 in human (A) and mouse (B) heart tissue lysates with GTX28025

REFERENCE
There are currently no references for BACE2 antibody (GTX28025). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for BACE2 antibody (GTX28025). Be the first to share your experience with this product.