GeneTex
United States (US)

BAFF antibody [Buffy XI]

img25848_18121411_562.jpg

Cat No. GTX16087

Host Mouse
Clonality Monoclonal
Clone Name Buffy XI
Isotype IgG1
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 μg/mL
Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Specificity/Sensitivity

This product does not react with Mouse.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BAFF (monoclonal Buffy-XI) antibody was raised against extracellular domain of human BAFF (aa. 137-285).

Purification

Purified IgG1

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Superfamily Member 13B,Baff,Blys,Cd257,Dtl,Tall-1,Tall1,Thank,Tnfsf20,Tnlg7A,Ztnf4,Tnfsf13B

Cellular Localization

Type II membrane protein. Also exists as an extracellular soluble form.

Background

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL1 (for TNF- and ApoL- related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NFkB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA. BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL,THANK was shown to activate NF-kB and c-jun N terminal kinase (JNK) and to induce apoptosis.

Database

DATA IMAGES
img25848_18121411_562.jpg

GTX16087 WB Image


Package List Price ($)
$ 319