GeneTex
United States (US)

BAIAP2 (isoform 1) antibody, C-term

GTX15697_1145_WB_18121410_325.jpg
GTX15697_184_IHC-P_18121410_961.jpg

Cat No. GTX15697

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-3μg/ml
IHC-P 5μg/ml
Not tested in other applications.

Calculated MW

61 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX15697-PEP).

Specificity/Sensitivity

This antibody is expected to recognise only human isoform 1 according to NP_059344.1.

Predict Reactivity

Mouse, Rat(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-SGSGTLVSTV, from the C Terminus of the protein sequence according to NP_059344.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Bai1 Associated Protein 2,Bap2,Flaf3,Irsp53,Baiap2

Cellular Localization

Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles.

Background

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Database

Research Area

DATA IMAGES
GTX15697_1145_WB_18121410_325.jpg

GTX15697 WB Image

WB analysis of human brain lysate using GTX15697 BAIAP2 (isoform 1) antibody, C-term.
Dilution : 1µg/ml
Loading : 35µg protein in RIPA buffer

GTX15697_184_IHC-P_18121410_961.jpg

GTX15697 IHC-P Image

IHC-P analysis of human cortex using GTX15697 BAIAP2 (isoform 1) antibody, C-term.
Antigen retrieval : citrate buffer pH 6
Dilution : 5µg/ml

Package List Price ($)
$ 319