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BAK antibody [TC100]

Anti-BAK antibody [TC100] used in Western Blot (WB). GTX10808

Cat. No. GTX10808

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 TC100

Isotype

 IgG2a

Application

 WB, IHC-Fr

Reactivity

 Human
Package
50 μg ($399)
See all BAK products

APPLICATION

Application Note

IHC-Fr: Use at a concentration of 1 - 5 μg/ml. WB: Use at a concentration of 2 - 5 μg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 23.4 kDa). Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

23 kDa. ( Note )

Positive Control

Tonsil.

PROPERTIES

Form

Liquid

Buffer

50mM Sodium Phosphate, 0.2% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment (C-terminal transmembrane portion deleted) (Human).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BCL2 antagonist/killer 1 , BAK , BAK-LIKE , BCL2L7 , CDN1

Cellular Localization

Mitochondrion outer membrane

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-BAK antibody [TC100] used in Western Blot (WB). GTX10808

GTX10808 WB Image

Detection of human Bak by immunoblotting. Sample: Whole cell lysates from untreated HL-60 cells. Primary antibody: Anti-Bak (Ab-1) Mouse mAb (TC-100) (GTX10808) (2 μg/ml). Detection: Chemiluminescence.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399