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BCL10 antibody [BL10/2988R]

Anti-BCL10 antibody [BL10/2988R] used in IHC (Paraffin sections) (IHC-P). GTX02597
Anti-BCL10 antibody [BL10/2988R] used in Flow cytometry (FACS). GTX02597
Anti-BCL10 antibody [BL10/2988R] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX02597

Cat. No. GTX02597

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 BL10/2988R

Isotype

 IgG

Application

 ICC/IF, IHC-P, FACS

Reactivity

 Human
Package
100 μg ($529)
See all BCL10 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 1-2 μg/ml
IHC-P 1-2 μg/ml
FACS 1-2 μg/million cells

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human BCL10 protein fragment (around aa122-168)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BCL10 immune signaling adaptor , CARMEN , CIPER , CLAP , IMD37 , c-E10 , mE10

Background

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Database

Research Area

DATA IMAGES

Anti-BCL10 antibody [BL10/2988R] used in IHC (Paraffin sections) (IHC-P). GTX02597

GTX02597 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX02597 BCL10 antibody [BL10/2988R].

Anti-BCL10 antibody [BL10/2988R] used in Flow cytometry (FACS). GTX02597

GTX02597 FACS Image

FACS analysis of PFA-fixed K562 cells using GTX02597 BCL10 antibody [BL10/2988R].
Blue : Primary antibody
Red : Isotype control

Anti-BCL10 antibody [BL10/2988R] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX02597

GTX02597 ICC/IF Image

ICC/IF analysis of PFA-fixed K562 cells using GTX02597 BCL10 antibody [BL10/2988R].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529