BCL10 antibody [BL10/411]

Cat No. GTX34423

Host	Mouse
Clonality	Monoclonal
Clone Name	BL10/411
Isotype	IgG1
Application	WB, IHC-P, FACS
Reactivity	Human
Package	100 μg ($469)

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Datasheet
Document

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1-2μg/ml
IHC-P	1-2μg/ml for 30 minutes at RT
FACS	1-2μg/10⁶ cells
Note : IHC-P Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.

Not tested in other applications.

Calculated MW

26 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human BCL10 recombinant protein (epitope aa122-168)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BCL10 , Bcell CLL/lymphoma 10 , CARMEN , CIPER , CLAP , IMD37 , cE10 , mE10 , BCL10 immune signaling adaptor

Cellular Localization

Cytoplasm,Perinuclear region,Membrane raft

Background

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Database

Gene ID: 8915 BCL10
UniProt: O95999 BCL10

Research Area

DATA IMAGES

GTX34423 WB Image

WB analysis of HepG2 cell lysate using GTX34423 BCL10 antibody [BL10/411].

GTX34423 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX34423 BCL10 antibody [BL10/411].

GTX34423 FACS Image

FACS analysis of PFA-fixed K562 cells using GTX34423 BCL10 antibody [BL10/411].
Blue : Primary antibody
Red : Isotype control

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μg

$ 469

Qty