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BCL10 peptide

Cat. No. GTX28430

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all BCL10 products

APPLICATION

Application Note

The peptide is used for blocking the activity of BcL10 (GTX28398)Incubatingthe peptide with equal volume of antibody for 30 min at 37ºC usually completely blocks theantibody activity in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, 10mM NaH₂PO₄, 10mM Na₂HPO₄, 130mM NaCl, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

B Cell Cll/Lymphoma 10 , Carmen , Ciper , Clap , Imd37 , C-E10 , Me10 , Bcl10

Background

Bcl10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (Caspase Recruitment Domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl 10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl10 cellular overexpression induces JNK, p38, and NF-kappaB activation. Deregulation of Bcl10 expression was also demonstrated to be involved in cellular oncogenesis.

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139