GeneTex
United States (US)

BCL6 antibody

GTX31491_2681_WB_20180221_18121410_863.jpg

Cat No. GTX31491

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

79 kDa. ( Note )

Positive Control

Rat Lung Tissue Lysate(GTX27941)

Specificity/Sensitivity

Three alternatively spliced transcript variants have been observed
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6.The immunogen is located within amino acids 370 - 420 of BCL6.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

B Cell Cll/Lymphoma 6,Bcl5,Bcl6A,Laz3,Zbtb27,Znf51,Bcl6

Background

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Database

Research Area

DATA IMAGES
GTX31491_2681_WB_20180221_18121410_863.jpg

GTX31491 WB Image

WB analysis of rat lung tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX31491 BCL6 antibody.
Working concentration : 1 μg/ml