APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| 1 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Rat Lung Tissue Lysate(GTX27941)
Specificity/Sensitivity
Three alternatively spliced transcript variants have been observed
PROPERTIES
Form
Liquid
Buffer
PBS with 0.02% sodium azide.
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6.The immunogen is located within amino acids 370 - 420 of BCL6.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
BCL6 transcription repressor , BCL5 , BCL6A , LAZ3 , ZBTB27 , ZNF51
Cellular Localization
Nucleus
Background
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Database
Research Area
DATA IMAGES
|
GTX31491 WB Image
WB analysis of rat lung tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX31491 BCL6 antibody.
Working concentration : 1 μg/ml
|
REFERENCE
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REVIEW
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