GeneTex

  • Country / Location Selection

United States (US)

BDNF antibody [35928.11]

Cat. No. GTX10832

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 35928.11

Isotype

 IgG1

Application

 WB, IHC-P, IHC-Fr

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all BDNF products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-2 μg/ml
IHC-P 8-25 μg/ml
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

28 kDa. ( Note )

Positive Control

human spinal cord

PROPERTIES

Form

Liquid

Buffer

PBS carbohydrates

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human BDNF, expressed in Sf 21 cells.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

brain derived neurotrophic factor , ANON2 , BULN2

Cellular Localization

Secreted

Background

Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non-neuronal cells.

Database

Research Area

REFERENCE

Clone Reference

N Mazzaro et al. J Neurosci 2016; 36 (7):2086-100 Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy
Application : IHC-Fr
Reactivity : Mouse
Submit a Reference

REVIEW

There are currently no reviews for BDNF antibody [35928.11] (GTX10832). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Package List Price ($)
$ 399