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BFAR antibody

Anti-BFAR antibody used in IHC (Paraffin sections) (IHC-P). GTX85010
Anti-BFAR antibody used in IHC (Paraffin sections) (IHC-P). GTX85010
Anti-BFAR antibody used in Western Blot (WB). GTX85010

Cat. No. GTX85010

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all BFAR products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Positive Control

Human Kidney Tissue Lysate(GTX29995)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BFAR antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human BFAR.The immunogen is located within amino acids 300 - 350 of BFAR.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

bifunctional apoptosis regulator , BAR , RNF47

Cellular Localization

Endoplasmic reticulum membrane

Background

The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.

Database

Research Area

DATA IMAGES

Anti-BFAR antibody used in IHC (Paraffin sections) (IHC-P). GTX85010

GTX85010 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX85010 BFAR antibody.
Working concentration : 5 μg/ml

Anti-BFAR antibody used in IHC (Paraffin sections) (IHC-P). GTX85010

GTX85010 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX85010 BFAR antibody.
Working concentration : 20 μg/ml

Anti-BFAR antibody used in Western Blot (WB). GTX85010

GTX85010 WB Image

WB analysis of human kidney tissue lysate using GTX85010 BFAR antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399