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BICD1 antibody

Anti-BICD1 antibody used in Western Blot (WB). GTX85029
Anti-BICD1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85029
Anti-BICD1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85029

Cat. No. GTX85029

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all BICD1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
ICC/IF 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

111 kDa. ( Note )

Positive Control

Daudi Cell Lysate(GTX23951)

Product Note

At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BICD1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human BICD1.The immunogen is located within the last 50 amino acids of BICD1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BICD cargo adaptor 1 , BICD , bic-D 1

Cellular Localization

Golgi apparatus

Background

BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells. At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.

Database

Research Area

DATA IMAGES

Anti-BICD1 antibody used in Western Blot (WB). GTX85029

GTX85029 WB Image

WB analysis of Daudi cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85029 BICD1 antibody.
Working concentration : 1 μg/ml

Anti-BICD1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85029

GTX85029 ICC/IF Image

ICC/IF analysis of Daudi cells using GTX85029 BICD1 antibody.
Working concentration : 2.5 μg/ml

Anti-BICD1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85029

GTX85029 ICC/IF Image

ICC/IF analysis of Daudi cells using GTX85029 BICD1 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399