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BIN1 antibody

Anti-BIN1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55538
Anti-BIN1 antibody used in Western Blot (WB). GTX55538
Anti-BIN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55538
Anti-BIN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55538
Anti-BIN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55538

Cat. No. GTX55538

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Rat
Package
100 μl ($399)
See all BIN1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:20 - 1:50
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

65 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1 (NP_647601.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

bridging integrator 1 , AMPH2 , AMPHL , CNM2 , SH3P9

Cellular Localization

Cytoplasm,Endosome

Background

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]

Database

Research Area

DATA IMAGES

Anti-BIN1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55538

GTX55538 ICC/IF Image

ICC/IF analysis of U2OS cells using GTX55538 BIN1 antibody.
Blue : DAPI

Anti-BIN1 antibody used in Western Blot (WB). GTX55538

GTX55538 WB Image

WB analysis of SW620 cell lysate using GTX55538 BIN1 antibody. The signal was developed with ECL plus-Enhanced.
Dilution : 1:1000
Loading : 25μg per lane

Anti-BIN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55538

GTX55538 IHC-P Image

IHC-P analysis of human gastric cancer tissue using GTX55538 BIN1 antibody.
Dilution : 1:200

Anti-BIN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55538

GTX55538 IHC-P Image

IHC-P analysis of rat brain tissue using GTX55538 BIN1 antibody.
Dilution : 1:100

Anti-BIN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55538

GTX55538 IHC-P Image

IHC-P analysis of human kidney tissue using GTX55538 BIN1 antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399