GeneTex
United States (US)

BLNK antibody [C3], C-term

GTX104614_WB_19011506_766.jpg
GTX104614_IFA_19011506_329.jpg

Cat No. GTX104614

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

Positive Control

HeLa , HepG2 , Molt-4 , Raji

Predict Reactivity

Mouse, Rat, Bovine(>80% identity)
PROPERTIES

Form

Liquid

Buffer

1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human BLNK. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

AGM4 antibody, BASH antibody, BLNK-S antibody, LY57 antibody, MGC111051 antibody, SLP-65 antibody, SLP65 antibody, BLNK antibody, B-cell linker protein antibody, cytoplasmic adapter protein antibody, B cell linker protein antibody, B-cell adapter containing a SH2 domain protein antibody, B-cell activation antibody, B-cell adapter containing a Src homology 2 domain protein antibody, Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody, Src homology 2 domain-containing leukocyte protein of 65 kDa antibody, B cell adaptor containing SH2 domain antibody, B-cell linker antibody

Cellular Localization

Cytoplasm , Cell membrane

Background

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX104614_WB_19011506_766.jpg

GTX104614 WB Image

Sample (30 ug of whole cell lysate)
A: Hela
10% SDS PAGE
GTX104614 diluted at 1:500

GTX104614_IFA_19011506_329.jpg

GTX104614 ICC/IF Image

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using B-cell linker protein(GTX104614) antibody at 1:200 dilution.

SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 319
$ 169