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BMPR1A antibody [8L7]

Anti-BMPR1A antibody [8L7] used in IHC (Paraffin sections) (IHC-P). GTX52504

Cat. No. GTX52504

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 8L7

Isotype

 IgG2

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all BMPR1A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:100 - 1:1000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

Product Note

This antibody was selected for its ability to detect human ALK3. No cross reactivity was found to ALK6 (BMPR-IB).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant hu-ALK3 extra cellular domain

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ACVRLK3 , ALK3 , BMPR1A , CD292 , SKR5 , bone morphogenetic protein receptor type 1A , 10q23del

Cellular Localization

Membrane

Background

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-BMPR1A antibody [8L7] used in IHC (Paraffin sections) (IHC-P). GTX52504

GTX52504 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52504 BMPR1A antibody [8L7].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399