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BMPR1B antibody [3E12]

Anti-BMPR1B antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX52506

Cat. No. GTX52506

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 3E12

Isotype

 IgG2

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all BMPR1B products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:100 - 1:1000
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

Product Note

This antibody was selected for its ability to detect human BMPR1B. No cross reactivity was found to ALK3 (BMPR-IA)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant hu-ALK6 extra cellular domain

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ALK6 , AMDD , BDA1D , BDA2 , BMPR1B , CDw293 , bone morphogenetic protein receptor type 1B , BMPR-IB

Cellular Localization

Cell membrane,Membrane

Background

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Database

Research Area

DATA IMAGES

Anti-BMPR1B antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX52506

GTX52506 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52506 BMPR1B antibody [3E12].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399