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BRCA1 antibody

Anti-BRCA1 antibody used in Immunohistochemistry (IHC). GTX70134

Cat No. GTX70134

Host

Mouse

Clonality

Polyclonal

Isotype

IgG

Application

WB, IP, IHC

Reactivity

Human
Package
50 μl ($319)

APPLICATION

Application Note

For IP: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Predicted molecular weight: 208 kDa. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

208 kDa. ( Note )

Positive Control

HBL100

PROPERTIES

Form

Liquid

Buffer

Anti-serum.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide from the human BRCA1 protein corresponding to carboxyl terminal amino acids 1848-1863 (QELDTYLIPQIPHSHY).

Purification

Unpurified
From polyclonal serum.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Brca1, Dna Repair Associated , Brcai , Brcc1 , Brovca1 , Fancs , Iris , Pnca4 , Ppp1R53 , Pscp , Rnf53 , Brca1

Cellular Localization

Nuclear

Background

BRCA1, a 220kDa nuclear phosphoprotein, is recognized by this antibody. Mutations in the BRCA1 tumor suppressor gene greatly increase the risk of breast cancer. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Recent studies suggest BRCA1 also has a role in DNA double strand break repair because of its association with Rad51.

Database

Research Area

DATA IMAGES

Anti-BRCA1 antibody used in Immunohistochemistry (IHC). GTX70134

GTX70134 IHC Image

REFERENCE

REVIEW

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