Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
A synthetic peptide from the human BRCA1 protein corresponding to carboxyl terminal amino acids 1848-1863 (QELDTYLIPQIPHSHY).
From polyclonal serum.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Brca1, Dna Repair Associated , Brcai , Brcc1 , Brovca1 , Fancs , Iris , Pnca4 , Ppp1R53 , Pscp , Rnf53 , Brca1
BRCA1, a 220kDa nuclear phosphoprotein, is recognized by this antibody. Mutations in the BRCA1 tumor suppressor gene greatly increase the risk of breast cancer. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Recent studies suggest BRCA1 also has a role in DNA double strand break repair because of its association with Rad51.