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BRCA1 antibody

Anti-BRCA1 antibody used in Immunohistochemistry (IHC). GTX70134

Cat No. GTX70134

Host

Mouse

Clonality

Polyclonal

Isotype

IgG

Application

WB, IP, IHC

Reactivity

Human
Package
50 μl ($379)

APPLICATION

Application Note

For IP: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Predicted molecular weight: 208 kDa. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

208 kDa. ( Note )

Positive Control

HBL100

PROPERTIES

Form

Liquid

Buffer

Serum

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide from the human BRCA1 protein corresponding to carboxyl terminal amino acids 1848-1863 (QELDTYLIPQIPHSHY).

Purification

Unpurified
From polyclonal serum.

Conjugation

Unconjugated

RRID

AB_368626

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BRCA1 DNA repair associated , BRCAI , BRCC1 , BROVCA1 , FANCS , IRIS , PNCA4 , PPP1R53 , PSCP , RNF53

Cellular Localization

Nucleus , Cytoplasm

Background

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]

Database

Research Area

DATA IMAGES

Anti-BRCA1 antibody used in Immunohistochemistry (IHC). GTX70134

GTX70134 IHC Image

REFERENCE

REVIEW

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Package List Price ($)
$ 379