Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Amino acids 2336-2478 of human BRCA2 expressed in E. coli. BRCA2-P400.
Protein G purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Brca2, Dna Repair Associated , Brcc2 , Brovca2 , Facd , Fad , Fad1 , Fancd , Fancd1 , Glm3 , Pnca2 , Xrcc11 , Brca2
BRCA2-5F6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.