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BRCA2 antibody

Anti-BRCA2 antibody used in Western Blot (WB). GTX51235
Anti-BRCA2 antibody used in IHC (Paraffin sections) (IHC-P). GTX51235

Cat. No. GTX51235

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μl ($399)
See all BRCA2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:300-1000
IHC-P 1:50-400
Not tested in other applications.

Calculated MW

384 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

1% BSA, 50% Glycerol

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human BRCA2(1-50).

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BRCA2 DNA repair associated , BRCC2 , BROVCA2 , FACD , FAD , FAD1 , FANCD , FANCD1 , GLM3 , PNCA2 , XRCC11

Cellular Localization

Nucleus

Background

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

Database

Research Area

DATA IMAGES

Anti-BRCA2 antibody used in Western Blot (WB). GTX51235

GTX51235 WB Image

WB analysis of various samples using GTX51235 BRCA2 antibody.
Dilution : 1:200
Lane 1 : MCF7 cell lysate
Lane 2 : CAPAN1 cell lysates

Anti-BRCA2 antibody used in IHC (Paraffin sections) (IHC-P). GTX51235

GTX51235 IHC-P Image

IHC-P analysis of human breast cancer tissue using GTX51235 BRCA2 antibody.
Dilution : 1:200

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399