APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.025 - 0.1 μg/ml |
Not tested in other applications.
Calculated MW
Product Note
The specific epitope is in the region between aa 550 and 600 of human BRD2.
Predict Reactivity
Bovine, Gorilla, Rhesus Monkey, Northern white-cheeked gibbon, crab-eating macaque, White-tufted-ear marmoset(>80% identity)
PROPERTIES
Form
Liquid
Buffer
Tris-Citrate/Phosphate
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Immunogen
Synthetic peptide representing a portion of the protein between the putative nuclear localization signal and the ET domain.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
BRD2 , D6S113E , FSH , FSRG1 , NAT , O27.1.1 , RING3 , RNF3 , bromodomain containing 2
Cellular Localization
Nucleus
Background
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
Database
Research Area
DATA IMAGES
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GTX19276 WB Image
WB analysis of extract (10ug) of HeLa cells untreated (-) or treated (+) with calf intestinal phosphatase using GTX19276 BRD2 antibody. Dilution : 0.05μg/ml
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REFERENCE
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REVIEW
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