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BRSK2 antibody

Anti-BRSK2 antibody used in Western Blot (WB). GTX85053
Anti-BRSK2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85053
Anti-BRSK2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85053

Cat. No. GTX85053

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all BRSK2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

82 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BRSK2 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human BRSK2.The immunogen is located within amino acids 630 - 680 of BRSK2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BR serine/threonine kinase 2 , C11orf7 , PEN11B , SAD1 , SADA , STK29

Cellular Localization

Endoplasmic reticulum

Background

BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2- mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.

Database

Research Area

DATA IMAGES

Anti-BRSK2 antibody used in Western Blot (WB). GTX85053

GTX85053 WB Image

WB analysis of human brain tissue lysate using GTX85053 BRSK2 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Anti-BRSK2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85053

GTX85053 IHC-P Image

IHC-P analysis of human brain tissue using GTX85053 BRSK2 antibody.
Working concentration : 20 μg/ml

Anti-BRSK2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85053

GTX85053 IHC-P Image

IHC-P analysis of human brain tissue using GTX85053 BRSK2 antibody.
Working concentration : 5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399