Preservative: NoneConstituents: BSA, Glycerol, Ethalene glycol. pH 7.4
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.75-1.2 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide: CNKNENMKRIFETDYVPHRLTS, corresponding to N terminal amino acids 200-221 of Drosophilia melanogaster Baboon. The peptide was amidated for conjugation.
Immunogen affinity purified
Purified against immobilized antigen based affinity chromatography which yielded an epitope specific antibody.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In higher vertebrates the patched (Ptc) also acts as a tumor suppressor. The patched receptor signaling involves negatively regulating a GPCR, smoothened. The binding Hedgehog ligand to Ptc removes the negative interaction of Ptc, and allows the signaling by smoothened. It has been shown that during head morphogenesis in D. melanogaster, Ptc positively interacts with smoothened, which leads to stimulation of Activin type 1 receptor Baboon, and activation of cell proliferation in the eye antennal disc. The expression of activated Baboon in the Ptc domain in Ptc mutant background completely abolish the head developmental defects.