PBS with 100ug BSA 0.1% sodium azide
Keep as concentrated solution, aliquot and store at 4ºC.
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Bcl2-Associated Athanogene 1,Bag-1,Rap46,Bag1
BAG 1 is a multifunctional protein that blocks apoptosis and interacts with several types of proteins. These include the Bcl 2 family proteins, the kinase Raf 1, certain tyrosine kinase growth factor receptors, and steroid hormone receptors, possibly by virtue of its ability to regulate the Hsp70 / Hsc70 family of molecular chaperones. BAG 1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. Human BAG 1 (hBAG 1) cDNA is identical to a hormone receptor binding protein RAP46. Human BAG 1 protein displays different isoforms of 36 kDa, 46 kDa, and 50 kDa.