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Bax antibody [2D3]

Anti-Bax antibody [2D3] used in Western Blot (WB). GTX16119

Cat. No. GTX16119

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2D3

Isotype

 IgG1

Application

 WB

Reactivity

 Human, Rat, Bovine, Cat, Dog
Package
50 μl ($399)
See all Bax products

APPLICATION

Application Note

WB: 1/10000. Predicted molecular weight: 21 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

21 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: MDGSGEQPRGGGPTSS, corresponding to amino acids 3-16 of Human Bax.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BCL2 associated X, apoptosis regulator , BCL2L4

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Bax antibody [2D3] used in Western Blot (WB). GTX16119

GTX16119 WB Image

MCF-7 activated with 1 μM Dexamethasone was separated on SDS-PAGE and probed with Monoclonal PA to BAX (MO) CL:2D2 (GTX16119). The antibody was developed with with Alkaline Phosphatase APA Mouse Fab ads HIgG conjugate and an NBT/BCIP substrate. Antibody dilution 5 μg/mL.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399