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Bax antibody [N1N2], N-term

Orthogonal
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Anti-Bax antibody [N1N2], N-term used in Immunoprecipitation (IP). GTX109683
Anti-Bax antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109683
Anti-Bax antibody [N1N2], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX109683
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683

Cat No. GTX109683

Reference 72
16

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IP

Reactivity

 Human, Mouse, Rat
Package
100 μl ($379),
25 μl ($169)
See all Bax products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr Assay dependent
IP 1:100-1:500
Not tested in other applications.

Calculated MW

21 kDa. ( Note )

Positive Control

Neuro2A , NIH-3T3 , Raw264.7 , C2C12 , PC-12 , Rat-2

Predict Reactivity

Bovine, Cat, Dog, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

1XPBS pH7, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.15 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Bax. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1949720

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BCL2 associated X, apoptosis regulator , BCL2L4

Cellular Localization

Isoform Alpha: Mitochondrion membrane , Cytoplasm , Isoform Beta: Cytoplasm , Isoform Gamma: Cytoplasm , Isoform Delta: Cytoplasm

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683

GTX109683 WB Image

Various tissue extracts (50 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bax antibody [N1N2], N-term (GTX109683) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683

GTX109683 WB Image

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bax antibody [N1N2], N-term (GTX109683) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683

GTX109683 WB Image

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bax antibody [N1N2], N-term (GTX109683) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bax antibody [N1N2], N-term used in Immunoprecipitation (IP). GTX109683

GTX109683 IP Image

Bax antibody [N1N2], N-term immunoprecipitates BCL2-associated X protein in IP experiments.
IP samples: MCF-7 whole cell extract
A. Control with 4 μg of preimmune Rabbit IgG
B. Immunoprecipitation of BCL2-associated X protein by 4 μg Bax antibody [N1N2], N-term (GTX109683)
15 % SDS-PAGE
The immunoprecipitated BCL2-associated X protein was detected by Bax antibody [N1N2], N-term (GTX109683) diluted at 1:500.
[EasyBlot anti-rabbit IgG (GTX221666-01) was used as a secondary reagent]
Anti-Bax antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109683

GTX109683 IHC-P Image

Bax antibody [N1N2], N-term detects Bax protein at cytoplasm on human lung carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human lung carcinoma.
Bax antibody [N1N2], N-term (GTX109683) diluted at 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Bax antibody [N1N2], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX109683

GTX109683 ICC/IF Image

Bax antibody [N1N2], N-term detects Bax protein at cytoplasm, nucleus and mitochondria by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: Bax protein stained by Bax antibody [N1N2], N-term (GTX109683) diluted at 1:400.
Blue: Hoechst 33342 staining.
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683

GTX109683 WB Image

Orthogonal

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bax antibody [N1N2], N-term (GTX109683) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.

Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683

GTX109683 WB Image

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bax antibody [N1N2], N-term (GTX109683) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

REFERENCE

Application Reference

Meng-Hui Zhang et al. Bioengineered 2022; 13 (4) : 10047-10060 Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway.
Application : WB
Chiang-Wen Lee et al. Molecules 2022; 27 (2) Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Jia-Wei Chen et al. Front Cell Neurosci 2022; 16 : 803718 mito-TEMPO Attenuates Oxidative Stress and Mitochondrial Dysfunction in Noise-Induced Hearing Loss via Maintaining TFAM-mtDNA Interaction and Mitochondrial Biogenesis.
Application : WB
Reactivity : Rat
Yang C et al. Oncol Lett 2022; 23 (4) : 139 NRBP1 negatively regulates SALL4 to reduce the invasion and migration, promote apoptosis and increase the sensitivity to chemotherapy drugs of breast cancer cells.
Application : WB
Reactivity : Human
Lee CW et al. Molecules 2022; 27 (2) : 373 Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Show More +
Submit a Reference

REVIEW

Bax antibody [N1N2], N-term Cat No. GTX109683

Rating
( Average 5 based on 16 users reviews)
Application
Western Blot(WB)
( Average 5 based on 15 users reviews)
IHC (Frozen sections)(IHC-Fr)
( Average 5 based on 1 users reviews)
Anti-Bax antibody [N1N2], N-term used in IHC (Frozen sections) (IHC-Fr). GTX109683
Date : Anonymous submitted on 10-Sep-2021
Score :
Application Tested : IHC-Fr
Sample Species : Rat
Sample : hippocampus
Blocking : 1% BSA in PBST, RT, 1Hr
Fixation : 4% PFA
Permeabilization /Antigen retrieval : 1% Triton and Citrate Buffer
Primary Antibody : 1:100, 4°C, > 12Hr
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : MDA-MB-231 cells
Amount used : 35
Blocking : 5% milk in TBST buffer, 25°C, 1Hr
Primary Antibody :
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Evid Based Complement Alternat Med in 2013.PMID: 23573126
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Stem Cell Res Ther in 2017.PMID: 28482861
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 05-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : U2OS cells
Amount used : 30 μg
Blocking : 5% non-fat dry milk in TBST, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 12Hr
Figure Note : 0-30 μM cisplatin treatment for 24hr.
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 03-Jun-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : Human brain tumor lysate
Amount used : 30 μg
Blocking : 5% milk in TBST, 25°C, 1Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Secondary Antibody : GTX300119, 1:2000, 25°C, 1Hr
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 30-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : HepG2 cells
Amount used : 20 μg
Blocking : 5% non-fat milk in TTBS, 22°C, 1Hr
Primary Antibody : 1:2000, 4°C, 18Hr
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2016. PMID: 26859149
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Molecules in 2017. PMID: 28531143
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Evid Based Complement Alternat Med in 2012. PMID: 23091557
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2017. PMID: 28467781
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2016. PMID: 26716417
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2016. PMID: 26716417
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2016. PMID: 26716417
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 26-May-2018
Score :
Application Tested : WB
Sample Species : Hu
Sample : MG63 cells
Amount used : 30 μg
Blocking : 5% non-fat dry milk in TBST, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Lane Description : Lane 1: Untreated MG63 whole cell lysate, Lane 2: Treated (IOX-1; 3uM) MG63 whole cell lysate, Lane 3: Treated (IOX-1; 10uM) MG63 whole cell lysateA:Untreated MG63 whole cell lysate
Anti-Bax antibody [N1N2], N-term used in Western Blot (WB). GTX109683
Date : Anonymous submitted on 15-Jan-2013
Score :
Application Tested : WB
Sample Species : Hu
Sample : U2OS cells
Amount used : 30μg
Blocking : 5% milk, 25°C, 1Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Show More +
Submit a Review
Application Reference
Meng-Hui Zhang et al. Bioengineered 2022; 13 (4):10047-10060 Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway.
Application : WB
Chiang-Wen Lee et al. Molecules 2022; 27 (2) Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Jia-Wei Chen et al. Front Cell Neurosci 2022; 16:803718 mito-TEMPO Attenuates Oxidative Stress and Mitochondrial Dysfunction in Noise-Induced Hearing Loss via Maintaining TFAM-mtDNA Interaction and Mitochondrial Biogenesis.
Application : WB
Reactivity : Rat
Yang C et al. Oncol Lett 2022; 23 (4):139 NRBP1 negatively regulates SALL4 to reduce the invasion and migration, promote apoptosis and increase the sensitivity to chemotherapy drugs of breast cancer cells.
Application : WB
Reactivity : Human
Lee CW et al. Molecules 2022; 27 (2):373 Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Zhen Tian et al. Cell Cycle 2021; 20 (9):874-893 Promoting roles of KLF5 in myocardial infarction in mice involving microRNA-27a suppression and the following GFPT2/TGF-β/Smad2/3 axis activation.
Application : WB
Reactivity : Rat
J Exp Med 2021; 218 (10) Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A.
Application : WB
Reactivity : Human
Yu-Chan Chang et al. Front Oncol 2021; 11:811635 Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer.
Application : WB
Reactivity : Human
Yuan-Kun Tu et al. Curr Neurovasc Res 2021; 18 (4):395-408 Human Olfactory Ensheathing Cell-derived Extracellular Cesicles: miRNA Profile and Neuroprotective Effect.
Application : WB
Reactivity : Human
Hongzhi Hu et al. J Nanobiotechnology 2021; 19 (1):390 Mitochondria-targeted accumulation of oxygen-irrelevant free radicals for enhanced synergistic low-temperature photothermal and thermodynamic therapy.
Application : WB
Reactivity : Human
Wang S et al. Aging (Albany NY) 2021; 13 (23):25241-25255 Endothelial cell-derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway.
Application : WB
Reactivity : Human
Xu C et al. Oxid Med Cell Longev 2021; 2021:2502324 Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm.
Application : WB
Reactivity : Mouse
Xie C et al. J Orthop Surg Res 2021; 16 (1):713 GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma.
Application : WB
Reactivity : Human
Zhang J et al. Mediators Inflamm 2021; 2021:6611085 Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice.
Application : WB
Reactivity : Mouse
Wang Y et al. Aging (Albany NY) 2020; 12 (20):20184-20197 Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice.
Lanzillotta C et al. Prog Neurobiol 2020;:101892 Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention.
Application : WB
Reactivity : Human
Chang JW et al. Cereb Cortex 2020; 30 (8):4597-4606 Ultrasound Stimulation Suppresses LPS-Induced Proinflammatory Responses by Regulating NF-κB and CREB Activation in Microglial Cells.
Application : WB
Reactivity : Rat
Wu Z et al. Cancer Cell Int 2020; 20:33 Mesenchymal stem cells derived from iPSCs expressing interleukin-24 inhibit the growth of melanoma in the tumor-bearing mouse model.
Application : WB
Reactivity : Mouse
Takino JI et al. Sci Rep 2019; 9 (1):16717 The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells.
Application : WB
Reactivity : Human
Chang WT et al. Int J Mol Sci 2019; 20 (17) C2-Ceramide-Induced Rb-Dominant Senescence-Like Phenotype Leads to Human Breast Cancer MCF-7 Escape from p53-Dependent Cell Death.
Reactivity : Human
Wei GJ et al. AAPS J 2019; 21 (5):86 A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation.
Application : WB
Reactivity : Human
Saat N et al. Biotech Histochem 2019;:1-7 Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus.
Reactivity : Rat
Dasgupta A et al. IUBMB Life 2019; (Epub) Astrakurkurone, a Sesquiterpenoid from Wild Edible Mushroom, Targets Liver Cancer Cells by Modulating Bcl-2 Family Proteins.
Application : WB
Reactivity : Human
Tang YJ et al. Drug Des Devel Ther 2019; 13:513-521 Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling.
Application : WB
Reactivity : Rat
Yu H et al. Microcirculation 2019;:e12537 Effect of mild hypothermia on cerebral microcirculation in a murine cardiopulmonary resuscitation model.
Application : WB
Reactivity : Rat
Abdel-Daim MM et al. Sci Total Environ 2019; 650 (Pt 2):2063-2073 Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: The antioxidant status and apoptotic markers expression in rats.
Application : IHC-P
Reactivity : Rat
Lee CW et al. J Cell Physiol 2018; (Epub) Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species.
Application : WB
Reactivity : Human
Tu HJ et al. Clin Epigenetics 2018; 10 (1):162 The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Application : WB
Reactivity : Human
Yan-Rou Tsai et al. Int. J. Mol. Sci. 2018; 19 (10):3252 Pomalidomide Ameliorates H2O2-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects.
Application : WB
Reactivity : Rat
Lee CF et al. Biomedicine (Taipei) 2018; 8 (3):15 benzyl isothiocyanate (bitc) triggers mitochondria-mediated apoptotic machinery in human *-resistant oral cancer car cells.
Application : WB
Reactivity : Human
Ibanez-Cabellos JS et al. Biochim Biophys Acta 2018; (Epub) Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells.
Application : WB
Reactivity : Human
Fan Z et al. Cell Physiol Biochem 2018; 47 (5):1977-1988 Bushenshugan Formula Attenuates the Development of Lung Cancer by Inhibiting Epithelial-Mesenchymal Transition.
Application : WB
Reactivity : Human
Dong T et al. Biomedicine & Pharmacotherapy 2018; 102:874-883 The protective roles of L-borneolum, D-borneolum and synthetic borneol in cerebral ischaemia via modulation of the neurovascular unit.
Application : IHC-P
Reactivity : Rat
Kim SH et al. Biomedicine & Pharmacotherapy 2018; 99:997-1008 Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.
Application : WB
Reactivity : Human
Chang HP et al. Int J Oncol 2018; (Epub) pterostilbene modulates the suppression of multidrug resistance protein-1 and triggers autophagic and apoptotic mechanisms in *-resistant human oral cancer car cells via akt signaling.
Application : WB
Reactivity : Human
Gunes-Bayir A et al. Mol Cell Biochem 2018; (Epub) Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.
Application : IHC-P
Reactivity : Rat
Azmy MS et al. Mol Neurobiol 2018; (Epub) neuroprotective effects of * in rotenone-induced parkinson's disease in rats: insights into its anti-inflammatory, neurotrophic, and antiapoptotic effects.
Application : IHC-P
Reactivity : Rat
Lin SC et al. Oncol Rep 2018; 39 (2):703-710 Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway.
Application : WB
Chang WT et al. Molecules 2017; 22 (5) A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression.
Li J et al. Stem Cell Res Ther 2017; 8 (1):107 therapeutic effect of urine-derived stem cells for */lipopolysaccharide-induced interstitial cystitis in a rat model.
Wu DD et al. Oncotarget 2017; 8 (30):49144-49155 extracellular signal-regulated kinase 8-mediated nf-κb activation increases sensitivity of human lung cancer cells to *.
Toraih EA et al. Tumour Biol 2017; 39 (11):1.01E+15 MicroRNA-target cross-talks: Key players in glioblastoma multiforme.
Application : IHC-P
Reactivity : Human
Lee WY et al. Int J Cancer 2017; 141 (9):1921-1931 * sensitizes kras-mutant non-small-cell lung cancer to * by targeting taz.
Application : WB
Reactivity : Human
Patricia Moreno-Londono A et al. Food Chem Toxicol 2017; 109 (Pt 1):143-154 isoliquiritigenin pretreatment attenuates * induced proximal tubular cells (llc-pk1) death and enhances the toxicity induced by this drug in bladder cancer t24-cell line.
Application : WB
Reactivity : Human
Briest F et al. Neuroendocrinology 2017; (Epub) Mechanisms of targeting the MDM2-p53-FOXM1 axis in well-differentiated intestinal neuroendocrine tumors.
Application : WB
Reactivity : Human
Tsui KH et al. Reproduction 2017; 154 (2):101-110 DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells.
Application : WB
Reactivity : Human
Lin LC et al. J Funct Foods 2017; 33:332-344 the licorice dietary component isoliquiritigenin chemosensitizes human uterine sarcoma cells to * and inhibits cell growth by inducing apoptosis and autophagy via inhibition of m-tor signaling.
Hsu SW et al. BMC Complement Altern Med 2017; 17 (1):29 Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway.
Application : WB
Reactivity : Rat
Xu YM et al. Oncotarget 2016; 7 (5):6146-58 Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.
Application : WB
Reactivity : Human
Chen MF et al. BMC Cancer 2016; 16:532 Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells.
Application : WB
Reactivity : Human
Chen PH et al. Neuropharmacology 2016; 110 (Pt A):362-75 The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death.
Application : WB
Reactivity : Human
Constantinescu AA et al. Mol Cell Biochem 2016; 418 (43102):91-102 Differential influence of * and * on mitochondrial-dependent signaling for apoptosis in pancreatic cells.
Application : WB
Reactivity : Human
Fu X et al. PLoS One 2016; 11 (2):e0148819 High-Dose Fluoride Impairs the Properties of Human Embryonic Stem Cells via JNK Signaling.
Application : WB
Reactivity : Human
Liu JJ et al. Int J Mol Sci 2015; 16 (8):19387-400 15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies.
Dagistan Y et al. World Neurosurg 2015; 84 (6):1739-46 Importance of IL-6, MMP-1, IGF-1, and BAX Levels in Lumbar Herniated Disks and Posterior Longitudinal Ligament in Patients with Sciatic Pain.
Application : IHC-P
Reactivity : Human
Lee WY et al. Oncotarget 2015; (Epub) repositioning antipsychotic * for treating colorectal cancer by inhibiting sirtuin 1.
Application : WB
Reactivity : Human
Li CJ et al. Sci Rep 2015; (Epub) Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.
Application : WB, ICC/IF
Reactivity : Human
Huang RF et al. Int J Nanomedicine 2015; 10:2823-46 Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene.
Application : WB
Reactivity : Human
Szu-Ting Lin et al. Cellular and Molecular Life Sciences 2015; 72 (12):2395-409 pgrmc1 contributes to *-induced chemoresistance in mes-sa uterine sarcoma.
Application : WB
Reactivity : Human
Luciani-Torres MG et al. Carcinogenesis 2014; Exposure to the polyester PET precursor - terephthalic acid induces and perpetuates DNA damage harboring non-malignant human breast cells.
Application : WB
Reactivity : Human
J. Abdi et al. The Journal of Nutritional Biochemistry 2014; Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells
Application : WB
Reactivity : Human
Rodriguez-Berna G et al. Eur J Med Chem 2014; 83C:366-373 A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.
Application : WB
Reactivity : Human
Lee JG et al. Toxicol In Vitro 2014; 28 (4):562-570 Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines.
Application : WB
Reactivity : Human, Rat
Abdi J et al. Blood Cancer J 2013; 3:e119 stimulation of toll-like receptor-1/2 combined with * increases cytotoxicity to human multiple myeloma cells.
Application : WB
Reactivity : Human
Wang LT et al. PLoS One 2013; 8 (11):e79814 Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury.
Application : WB
Hsu YL et al. PLoS One 2013; 8 (11):e79518 protective roles of *-induced protein with tetratricopeptide repeats 3 (ifit3) in dengue virus infection of human lung epithelial cells.
Application : WB
Reactivity : Human
Chen YW et al. Evid Based Complement Alternat Med 2013; 2013:364519 Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury.
Application : WB
Reactivity : Rat
Chen JH et al. Food Chem Toxicol 2013; 51:446-52 Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cells.
Li CJ et al. Evid Based Complement Alternat Med 2012; 2012:261971 Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways.
Application : WB
Reactivity : Human
Li CJ et al. Cancer Lett 2012; 319 (2):203-13 synergistic anticancer activity of triptolide combined with * enhances apoptosis in gastric cancer in vitro and in vivo.
Application : ICC/IF
Reactivity : Human
Liu CH et al. J Ethnopharmacol 2011; 137 (1):503-11 Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.
Application : WB
Reactivity : Human
Hsu YF et al. Biochim Biophys Acta 2011; 1810 (5):504-13 p53 in trichostatin A induced C6 glioma cell death.
Application : WB
Reactivity : Rat
SDS
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