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Bcl-X antibody [2H12]

Anti-Bcl-X antibody [2H12] used in IHC (Paraffin sections) (IHC-P). GTX23193

Cat. No. GTX23193

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2H12

Isotype

 IgG2a

Application

 WB, ICC/IF, IHC-P, FACS

Reactivity

 Human, Mouse, Rat, Pig
Package
500 μl ($399)
See all Bcl-X products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
FACS Assay dependent
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

Positive Control

Hodgkin's lymphoma

Product Note

GTX23193 reacts with both Bcl-XS and Bcl-XL proteins.

PROPERTIES

Form

Liquid

Buffer

BSA

Preservative

Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein. This amino acid sequence is shared by human and murine Bcl-X protein.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BCL2 like 1 , BCL-XL/S , BCL2L , BCLX , Bcl-X , PPP1R52

Cellular Localization

Mitochondrion outer membrane,Mitochondrion matrix,Cytoplasm, cytosol

Background

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]

Database

Research Area

DATA IMAGES

Anti-Bcl-X antibody [2H12] used in IHC (Paraffin sections) (IHC-P). GTX23193

GTX23193 IHC-P Image

Formalin-fixed, paraffin-embedded human Hodgkins lymphoma stained with GTX23193 using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of Reed-Sternberg cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399