GeneTex
United States (US)

Bcl2A1 antibody

Anti-Bcl2A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31738
Anti-Bcl2A1 antibody used in Western Blot (WB). GTX31738
Anti-Bcl2A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31738

Cat No. GTX31738

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

20 kDa. ( Note )

Positive Control

Human Lung Tissue Lysate(GTX27917) , Mouse Kidney Tissue Lysate(GTX27936) , Human Kidney Tissue Lysate(GTX29995)

Specificity/Sensitivity

At least two isoforms are known to exist; this antibody will only detect the larger isoform.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Bcl2A1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Bcl2A1.The immunogen is located within the last 50 amino acids of Bcl2A1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Bcl2 Related Protein A1,Acc-1,Acc-2,Acc1,Acc2,Bcl2L5,Bfl1,Grs,Hbpa1,Bcl2A1

Background

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-Bcl2A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31738

GTX31738 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX31738 Bcl2A1 antibody.
Working concentration : 20 μg/ml

Anti-Bcl2A1 antibody used in Western Blot (WB). GTX31738

GTX31738 WB Image

WB analysis of (A) human kidney and (B) human lung tissue lysate using GTX31738 Bcl2A1 antibody.
Working concentration : 1 μg/ml

Anti-Bcl2A1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31738

GTX31738 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX31738 Bcl2A1 antibody.
Working concentration : 10 μg/ml

Package List Price ($)
$ 329