APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 20 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Kidney Tissue Lysate(GTX29995)
Product Note
At least two isoforms are known to exist; this antibody will detect both isoforms.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Bcl2A1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Bcl2A1.The immunogen is located within the first 50 amino acids of Bcl2A1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
BCL2 related protein A1 , ACC-1 , ACC-2 , ACC1 , ACC2 , BCL2L5 , BFL1 , GRS , HBPA1
Cellular Localization
Cytoplasm
Background
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX31739 WB Image
WB analysis of human kidney tissue lysate using GTX31739 Bcl2A1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
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GTX31739 IHC-P Image
IHC-P analysis of mouse kidney tissue using GTX31739 Bcl2A1 antibody.
Working concentration : 2 μg/ml
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GTX31739 IHC-P Image
IHC-P analysis of mouse kidney tissue using GTX31739 Bcl2A1 antibody.
Working concentration : 20 μg/ml
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REFERENCE
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REVIEW
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