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Beclin 1 antibody

Orthogonal
Anti-Beclin 1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX37770
Anti-Beclin 1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX37770
Anti-Beclin 1 antibody used in Western Blot (WB). GTX37770
Anti-Beclin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX37770
Anti-Beclin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX37770
Anti-Beclin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX37770

Cat. No. GTX37770

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IHC-Fr

Reactivity

 Human, Mouse, Rat
Package
100 μg ($459)
See all Beclin 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:100-2000
IHC-P 1:100-600
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

52 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human Beclin 1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_11167273

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

beclin 1 , ATG6 , VPS30 , beclin1

Cellular Localization

Cytoplasm,Endosome membrane,Endoplasmic reticulum membrane,Endosome,Nucleus

Background

This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Database

Research Area

DATA IMAGES

Anti-Beclin 1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX37770

GTX37770 IHC-Fr Image

IHC-Fr analysis of rat lymph node tissue using GTX37770 Beclin 1 antibody.
Dilution : 2.5μg/ml

Anti-Beclin 1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX37770

GTX37770 IHC-Fr Image

IHC-Fr analysis of rat pancreas tissue using GTX37770 Beclin 1 antibody.
Dilution : 2.5μg/ml

Anti-Beclin 1 antibody used in Western Blot (WB). GTX37770

GTX37770 WB Image

WB analysis of rat lymph node (Lane 1), mouse spinal cord (Lane 2), rat rectum (Lane 3), mouse testis (Lane 4), human breast cancer (Lane 5), rat pancreas (Lane 6) tissue lysates using GTX37770 Beclin 1 antibody.
Dilution : 1μg/ml

Anti-Beclin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX37770

GTX37770 IHC-P Image

IHC-P analysis of human breast cancer tissue using GTX37770 Beclin 1 antibody.
Dilution : 2.5μg/ml

Anti-Beclin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX37770

GTX37770 IHC-P Image

IHC-P analysis of rat lymph node tissue using GTX37770 Beclin 1 antibody.
Dilution : 2.5μg/ml

Anti-Beclin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX37770

GTX37770 IHC-P Image

Orthogonal

The data was published in the journal Int J Mol Sci in 2020.PMID: 32046105

REFERENCE

Application Reference

Scherr AL et al. Int J Mol Sci 2020; 21 (3) Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells.
Application : IHC-P
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 459